Key Publications

Arnold IC and Munitz A. "Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease". Nat Rev Immunol. 2024

Borrelli C and Gurtner A, Arnold IC and Moor AE. "Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils". Nature Protocols 2024

Gurtner A, Crepaz D and Arnold IC. "Emerging functions of tissue-resident eosinophils". J Exp Med. 2023

Gurtner A and Borrelli C, Gonzalez-Perez I, Bach K, Acar IE, Núñez NG, Crepaz D, Handler K, Vu VP, Lafzi A, Stirm K, Raju D, Gschwend J, Basler K, Schneider C, Slack E, Valenta T, Becher B, Krebs P, Moor AE and Arnold IC. "Active eosinophils regulate host defence and immune responses in colitis". Nature. 2023

Arnold IC. "Adapting to their new home: eosinophils remodel the gut architecture". J Exp Med. Insight 2022

Fallegger A, Priola M, Artola-Borán M, Núñez NG, Wild S, Gurtner A, Becher B, Yousefi S, Simon HU, Arnold IC* and Müller A*. "TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin- RORγt+ regulatory T-cells during bacterial and allergen challenge". Mucosal Immunol. 2022

Gurtner A, Gonzalez-Perez I, Arnold IC. "Intestinal eosinophils, homeostasis and response to bacterial intrusion". Semin Immunopathol. 2021

Simon HU, Shida Yousefi S, Germic N, Arnold IC, Haczku A, Karaulov A, Simon D, Rosenberg HF "The Cellular Functions of Eosinophils – Collegium". Int Arch Allergy Immunol. 2020

Arnold IC, Artola-Boran M, Gurtner A, Katrin Bertram K, Bauer M, Frangez Z, Becher B, Kopf M, Yousefi S, Simon HU, Tzankov A, Müller A. "The GM-CSF/IRF5 signaling axis in eosinophils promotes anti-tumor immunity through activation of type I T-cell responses". J Exp Med. 2020

Arnold IC* and Zhang X*, Artola-Boran M, Fallegger A, Sander P, Johansen P, Müller A.
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues.
PLoS Pathog, 2019.

Pachathundikandi SK, Tegtmeyer N, Arnold IC, Lind J, Neddermann M, Falkeis-Veits C, Chattopadhyay S, Brönstrup M, Tegge W, Hong M, Sticht H, Vieth M, Müller A, Backert S.
T4SS-dependent TLR5 activation by Helicobacter pylori infection.
Nat Commun. 2019

Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold IC, Franchini F, Chomka A, Ilott NE, Johnston DGW, Pires E, McCullagh J, Sansom SN, Arancibia-Cárcamo CV, Uhlig HH, Powrie F.
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
Immunity, 2019

Arnold IC, Artola-Boran M, Tallón de Lara P, Kyburz A, Taube C, Ottemann K, van den Broek M, Yousefi S, Simon HU, Müller A.
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
 J. Exp. Med, 2018.    

Arnold IC, Zhang X, Urban S, Artola-Borán M, Manz MG, Ottemann KM, Müller A.
NLRP3 controls the development of gastrointestinal CD11b+ dendritic cells in the steady state and during chronic bacterial infection.
Cell Rep, 2017

Arnold IC* and Mathisen S*, Schulthess J, Danne C, Hegazy AN, Powrie F
CD11c+ monocytes/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.
Mucosal Immunol, 2016

Arnold IC* and Griseri T*, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F.
GM-CSF -activated eosinophils promote Interleukin-23 driven chronic colitis.
Immunity, 2015
    
Arnold IC, Hutchings C, Kondova I, Hey A, Powrie F, Beverley P, Tchilian E.
Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.
Vaccine, 2015

Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, Müller A
Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells.
J Clin Invest, 2011

Arnold IC, Lee JY, Amieva MR, Roers A, Flavell RA, Sparwasser T, Müller A.
Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.
Gastroenterology, 2011

*these authors contributed equally