Selected Publications

Mononuclear phagocytes in autoimmune neuroinflammation. Gogoleva VS, Mundt S, De Feo D, Becher B. Trends Immunol. 2024 Sep 21:S1471-4906(24)00191-1. https://doi.org/10.1016/j.it.2024.08.005

Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation. Villar-Vesga J., De Feo D., Clément P., Ingelfinger F., Ulutekin C., Kim J., Pena-Francesch M., Schmidt K. W., Meuffels E., Bugada V., Greis D., Costa-Pereira S., Oberbichler L., Seehusen F., Prisco F., Dalvi U., Münz C., Saab A. S., Becher B., Mundt S. bioRxiv [Preprint]. 2024.09. 18.612891 https://doi.org/10.1101/2024.09.18.612891

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells. Costa-Pereira S., Lanzinger M., Andreadou M., Nunez N., Villar-Vesga J., Prisco F., Häne P., Roussel E., Krishnarajah S., Lindemann R. C., Westermann F., Oberbichler L., Sethi A., Fonseca Da Silva A., Lutz M., Tugues S., Mundt S., Kipar A., Greter M., De Feo D*., Becher B*. bioRxiv [Preprint]. 2024.01. 24.577048 https://doi.org/10.1101/2024.01.24.577048 *Co-last authorship, equally contributed.

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice. Andreadou M§, Ingelfinger F§, De Feo D*, Cramer TLM, Tuzlak S, Friebel E, Schreiner B, Eede P, Schneeberger S, Geesdorf M, Ridder F, Welsh CA, Power L, Kirschenbaum D, Tyagarajan SK, Greter M, Heppner FL, Mundt S, Becher B. Nat Neurosci. 2023 Oct;26(10):1701-1712. https://doi.org/10.1038/s41593-023-01435-z. §Co-First authorship, *Second authorship

Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors. Liu Z, Wang H, Li Z, Dress RJ, Zhu Y, Zhang S, De Feo D, Kong WT, Cai P, Shin A, Piot C, Yu J, Gu Y, Zhang M, Gao C, Chen L, Wang H, Vétillard M, Guermonprez P, Kwok I, Ng LG, Chakarov S, Schlitzer A, Becher B, Dutertre CA, Su B, Ginhoux F. Immunity. 2023 Aug 8;56(8):1761-1777.e6. https://doi.org/10.1016/j.immuni.2023.07.001.

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology. Gullotta GS*, De Feo D*, Friebel E, Semerano A, Scotti GM, Bergamaschi A, Butti E, Brambilla E, Genchi A, Capotondo A, Gallizioli M, Coviello S, Piccoli M, Vigo T, Della Valle P, Ronchi P, Comi G, D'Angelo A, Maugeri N, Roveri L, Uccelli A, Becher B, Martino G, Bacigaluppi M. Nat Immunol. 2023 May 15. https://doi.org/10.1038/s41590-023-01505-1. *Co-First authorship, equally contributed.

CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12. Paust HJ*, Song N*, De Feo D*, Asada N, Tuzlak S, Zhao Y, Riedel JH, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel UO, Steinmetz OM, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer MT, Hoxha E, Stahl RAK, Huber TB, Bonn S, Meyer-Schwesinger C, Wiech T, Turner JE, Becher B, Krebs CF, Panzer U. Sci Transl Med. 2023 Mar 15;15(687):eadd6137. https://doi.org/10.1126/scitranslmed.add6137. Co-First authorship, equally contributed.

Twin study reveals non-heritable immune perturbations in multiple sclerosis. Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B. Nature. 2022 Mar;603(7899):152-158. https://doi.org/10.1038/s41586-022-04419-4

IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation. Amorim A*, De Feo D*, Friebel E*, Ingelfinger F, Anderfuhren CD, Krishnarajah S, Andreadou M, Welsh CA, Liu Z, Ginhoux F, Greter M, Becher B. Nat Immunol. 2022 Feb;23(2):217-228. https://doi.org/10.1038/s41590-021-01117-7 *Co-first authorship, equally contributed.

Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice. Sinduya Krishnarajah, Florian Ingelfinger, Ekaterina Friebel, Dilay Cansever, Ana Amorim, Myrto Andreadou, David Bamert, Gioana Litscher, Mirjam Lutz, Maud Mayoux, Sarah Mundt, Frederike Ridder, Colin Sparano, Sebastian Anton Stifter, Can Ulutekin, Susanne Unger, Marijne Vermeer, Pascale Zwicky, Melanie Greter, Sonia Tugues, Donatella De Feo*, Burkhard Becher*. Nature Aging 2022 Jan; 2(1): 74-89. https://doi.org/10.1038/s43587-021-00148-x *Co-last authorship, equally contributed.

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation. Ingelfinger F*, De Feo D*, Becher B. Semin Immunol. 2021 Apr;54:101518. https://doi.org/10.1016/j.smim.2021.101518 *Equally contributed.

Skipping adolescence to become super-inflammatory monocytes. Becher B, De Feo D, Amorim A, Greter M. Nat Immunol. 2020 May;21(5):491-492. https://doi.org/10.1038/s41590-020-0652-2

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells. Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B. Sci Transl Med. 2018 Nov 28;10(469):eaat8410. https://doi.org/10.1126/scitranslmed.aat8410.