Publications

2023
- Welsh JA*, Goberdhan DCI*,  O'Driscoll L*, ... , Chahwan R, ... , Théry C*, & Witwer KW*. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. (accepted)
- Modular Cytosine Base Editing Promotes Epigenomic and Genomic Modifications. Weischedel J, Higgins L, Rogers S, Gramalla-Schmitz A, Wyrzykowska P,  Borgoni S, MacCarthy T, Chahwan R*. Nucleic Acids Research; gkad1118.doi: 10.1093/nar/gkad1118
- Assessing extracellular vesicles in human biofluids using flow-based analyzers. Yim KHW^, Krzyzaniak O^, Al Hrout A, Peacock B, & Chahwan R*. Adv Healthc Mater; 2301706. doi: 10.1002/adhm.202301706
- Investigating The Tumor-Immune Microenvironment Through Extracellular Vesicles From Frozen Patient Biopsies. Al Hrout A, Levesque M, & Chahwan R*. Front Immunol; May 25;14:1176175.  doi: 10.3389/fimmu.2023.1176175.
- Juan, M., Plebanski, M., eds. (2023). Methods in cancer immunity and immunotherapy: 2022. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-8325-3731-2
 
2022
- Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Wang S, Lee K, Gray S, Zhang Y, Tang C, Morrish RB, Tosti E, van Oers J, Cohen P, MacCarthy T, Roa S*, Scharff MD*, Edelmann W*, Chahwan R*. Nucleic Acids Research; gkac616. doi.org/10.1093/nar/gkac616
- Predictive and Prognostic Value of Non-coding RNA in Breast Cancer. Sobhani N, Chahwan R, Roudi R, Morris R, Volinia S, Chai D, D'Angelo A, Generali D. Cancers. 14(12), 2952.
- Modelling liver cancer microenvironment using a novel 3D culture system. Al Hrout A, Cervantes-Gracia K, Amin A*, & Chahwan R*. Sci Rep; 12:8003. doi: 10.1038/s41598-022-11641-7
- Serum extracellular vesicles profiling is associated with COVID-19 progression and immune responses. Yim KHW, Borgoni S, & Chahwan R*. J Extracell Bio; 00, e38. doi: 10.1002/jex2.37.
- Integrative OMICS data-driven procedure using a derivatized meta-analysis approach. Cervantes-Gracia K, Chahwan R*, & Holger Husi*. Front Genet; 13:828786. doi: 10.3389/fgene.2022.828786.
 
2021
- Measuring Real-time DNA/RNA nuclease activity through fluorescence. Wyrzykowska P, Rogers S, & Chahwan R*. BioProtocol. 2021. 11(21): e4206. doi: 10.21769/bioprotoc.4206.
- APOBECs orchestrate genomic and epigenomic editing across health and disease. Cervantes-Gracia K^, Gramalla-Schmitz A^, Weischedel J, & Chahwan R*. Trends in Genetics. 2021, Aug 2:S0168-9525(21)00193-1
- Integrative analysis of Incongruous Cancer Genomics and Proteomics Datasets. Cervantes-Gracia K, Chahwan R, & Husi H*.  Methods Mol Biol. 2021;2361:291-305.
- Functional Phenotype Flow Cytometry: On Chip Sorting of Individual Cells According to Responses to Stimuli.  Nikiforov PO, Hejja B, Chahwan R, Soeller C, Gielen F, & Chimerel C*. Adv Biol. 2021 Jun23:e2100220.
- Editorial: “Probing the Chromatin Architecture". Palombo F*, Pagliara S, Singh A, & Chahwan R. Front. Cell Dev Biol. 2021, 2021.727803
- Single cell label-free probing of chromatin dynamics during B lymphocyte maturation. Morrish RM^, Yim KHW^, Pagliara S*, Palombo F*, Chahwan R*, & Stone N*. Front. Cell Dev Biol. 2021, Mar 26;9:646616. ^ and * equally contributing authors
- Integrative analysis of Incongruous Cancer Genomics and Proteomics Datasets. Cervantes-Gracia K, Chahwan R, & Husi H*.  Proteomics Data Analysis, 2021 pp 291-305. Humana, New York, NY
 
2020
- Extracellular Vesicles Orchestrate Immune and Tumor Interaction Networks. Yim KHW, Al Hrout A, Borgoni, S, Chahwan R*. Cancers. 2020, 12, 3696.
- Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy. Cervantes-Gracia K, Raja K, Llanas-Cornejo D, Cobley JN, Megson IL, Chahwan R, Holger Husi*. Vessel Plus. 2020; 4:27
 
2019
- Single cell imaging of nuclear architecture changes. Morrish RM, Hermes M, Metz J, Stone N, Pagliara S*, Chahwan R* & Palombo F*.  Front. Cell Dev Biol. 2019, Jul 24;7:141.    * equally contributing authors
- A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity. Sheppard E^, Rogers S^, Harmer N, Chahwan R*. Scientific Reports. 2019, 9: 8853.
 
2018
- Epigenomic Modifications Mediating Antibody Maturation. Sheppard EC^, Morrish RB^, Dillon MJ, Leyland R, Chahwan R*. Front Immunol. 2018. Feb 26;9:355.
 
2016
- Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens. Harmer NJ, Chahwan R*. Virulence. 2016 Aug 17;7(6):623-6.
- Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation. Wang S, Chahwan R, Wei L, Scharff MD. Encyclopedia in Immunobiology, Volume 2, 2016, Pages 126-133
 
2015
- Overlapping hotspots in CDRs are critical sites for V region diversification. Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T*. PNAS. 2015 Feb 2. pii: 201500788.
- Somatic Hypermutation: The Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies. Martin A, Chahwan R, Parsa J, Sharff MD. Molecular Biology of B cells, chapter 20. Elsevier, 2nd ed, 2015, Pages 363-388.
 
 
2014
- The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W*. Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365.
 
 
2013
- Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Chahwan R^, Schaetzlein S^, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W*. PNAS. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110.
- RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures. Chahwan R^*, Gravel S^, Matsusaka T, Jackson SP*. Cell Cycle. 2013 Apr 15;12(8):1161. doi: 10.4161/cc.24402.
- Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Chahwan R^*, Gravel S^, Matsusaka T, Jackson SP*. Cell Cycle. 2013 Mar 15;12(6):1000-8. doi: 10.4161/cc.23947.
 
2012
- AIDing antibody diversity by error-prone mismatch repair. Chahwan R, Edelmann W, Scharff MD, Roa S. Semin Immunol. 2012 Aug;24(4):293-300. doi: 10.1016/j.smim.2012.05.005. Epub 2012 Jun 14. Review.
- The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. Chahwan R, et al. J Exp Med. 2012 Apr 9;209(4):671-8. doi: 10.1084/jem.20111531.
- Aicardi-Goutieres syndrome: from patients to genes and beyond. Chahwan C*, Chahwan R*. Clin Genet. 2012 May;81(5):413-20. doi: 10.1111/j.1399-0004.2011.01825.x. Epub 2012 Jan 8. Review.
 
2011
- Mismatch-mediated error prone repair at the immunoglobulin genes. Chahwan R, Edelmann W, Scharff MD, Roa S. Biomed Pharmacother. 2011 Dec;65(8):529-36. doi: 10.1016/j.biopha.2011.09.001. Review.
- The multidimensional nature of epigenetic information and its role in disease. Chahwan R*, Wontakal SN*, Roa S*. Discov Med. 2011 Mar;11(58):233-43. Review.
 
2010
- Crosstalk between genetic and epigenetic information through cytosine deamination. Chahwan R*, Wontakal SN*, Roa S*. Trends Genet. 2010 Oct;26(10):443-8. doi: 10.1016/j.tig.2010.07.005. Epub 2010 Aug 26.
- The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Chahwan R^, Ramachandran S^, et al. PNAS 2010 Jan 12;107(2):809-14. doi: 10.1073/pnas.0913790107.
 
2001-2007
- Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, et al. Science. 2007 Dec 7;318(5856):1637-40.
- Involvement of mammalian Mus81 in genome integrity and tumor suppression. McPherson JP, Lemmers B, Chahwan R, et al. Science. 2004 Jun 18;304(5678):1822-6.
- Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, et al. EMBO J. 2003 Nov 17;22(22):6137-47.